Dosing & Administration

Dosing

PLUVICTO IS ADMINISTERED EVERY 6 WEEKS FOR UP TO 6 DOSES^1,2

PLUVICTO can be administered multiple ways and only needs to be administered once every 6 weeks for up to 6 doses.*

• PLUVICTO solution for injection contains 7.4 GBq (200 mCi) (at time of use)

• Slow IV injection (1 to 10 minutes) or infusion

GBq, gigabecquerel; IV, intravenous; mCi, millicurie.
*Or until disease progression or unacceptable toxicity.

Dose Modifications

DOSE MODIFICATIONS FOR ADVERSE REACTIONS¹

Management of adverse reactions may require temporary dose interruption (extending the dosing interval from every 6 weeks up to every 10 weeks), dose reduction, or permanent discontinuation of treatment with PLUVICTO.

Recommended dosage modifications of PLUVICTO for adverse reactions 

Administration

SETUP AND ADMINISTRATION OF PLUVICTO¹

General information

• PLUVICTO is administered intravenously

• Nuclear medicine health care professionals may use methods deemed appropriate and safe

• Prior to administration with PLUVICTO, a saline flush with ≥10 mL of 0.9% sterile sodium chloride must be administered to ensure patency of the IV line and minimize the risk of extravasation

• Manage cases of extravasation as per your institutional guidelines

• PLUVICTO will be administered slowly by intravenous route and followed by a saline flush

Radiation Safety

IMPORTANT NOTE REGARDING USE OF PLUVICTO³

Always use the principles of ALARA (as low as reasonably achievable)

ALARA is the guiding principle of radiation safety. It means that even a small radiation dose should be avoided if there is no benefit to receiving it. It includes 3 basic protective measures:

Any unused medicinal product or waste material should be disposed of in accordance with local and federal laws.